The current research is carried out to search out the efficacy of plant extracts to behave as mosquito repellents. Initially, the larvicidal exercise of the extracts and the toxicity research was carried out. From the outcomes, the extracts with most larvicidal exercise and the minimal toxicity had been used for the additional evaluation. The least toxicity was noticed with the ethanol extracts of Lantana camara, Tagetes erecta and Tanacetum cineriifolium. The Lanatana camara and Tanacetum cineriifolium confirmed the utmost larvicidal exercise. The DNA sugar harm assay is carried out and browse at 532 nm. The hemolytic exercise of the extract is carried out and the outcomes point out that the extracts confirmed no hemolytic exercise on the focus of 100 and 200mg/L. Only the flower extracts of Tagaetes erecta, Lantana camara and Tanacetum cineriifolium confirmed reasonable hemolytic exercise at 500 and 1000 mg/L. Finally, the HPLC evaluation of the extracts confirmed that the ethanol extracts of Lantana camara and Tanacetum cineriifloium revealed the presence of marker compound. Therefore the ethanol extracts of Lantana camara and Tanacetum cineriifolium had been taken up for the membrane stabilization assay. The pores and skin irritation potential of the cream ready utilizing the ethanol extract of Tanacetum cineriifolium was analysed, the cream confirmed no irritation.